Author Affiliations
Abstract
1 State Key Laboratory of Modern Optical Instrumentations, Centre for Optical and Electromagnetic Research, College of Optical Science and Engineering, International Research Center for Advanced Photonics, Zhejiang University, Hangzhou 310058, P. R. China
2 Department of Chemistry, The Hong Kong Branch of Chinese, National Engineering Research Center for Tissue Restoration and Reconstruction, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong 999077, P. R. China
3 Shenzhen Research Institute of Shandong University, Shenzhen 518057, P. R. China
4 Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310000, P. R. China
5 School of Science and Engineering, Shenzhen Institute of Aggregate Science and Technology, The Chinese University of Hong Kong, Shenzhen, Guangdong 518172, P. R. China
Lipid droplets (LDs) participate in many physiological processes, the abnormality of which will cause chronic diseases and pathologies such as diabetes and obesity. It is crucial to monitor the distribution of LDs at high spatial resolution and large depth. Herein, we carried three-photon imaging of LDs in fat liver. Owing to the large three-photon absorption cross-section of the luminogen named NAP-CF3 (cm6 s2), three-photon fluorescence fat liver imaging reached the largest depth of 80m. Fat liver diagnosis was successfully carried out with excellent performance, providing great potential for LDs-associated pathologies research.
Lipid droplets three-photon fluorescence microscopy fat liver deep-tissue imaging Journal of Innovative Optical Health Sciences
2023, 16(4): 2250033
Author Affiliations
Abstract
1 The Hong Kong University of Science and Technology, Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, and Guangdong-Hong Kong-Macau Joint Laboratory of Optoelectronic and Magnetic Functional Materials, Clear Water Bay, Kowloon, Hong Kong, China
2 Zhejiang University, MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Hangzhou, China
3 ZJU-Hangzhou Global Scientific and Technological Innovation Center, Hangzhou, China
4 South China University of Technology, Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates, Guangzhou, China
5 The Chinese University of Hong Kong, Shenzhen Institute of Aggregate Science and Technology, School of Science and Engineering, Shenzhen, China
6 AIE Institute, Guangzhou Development District, Guangzhou, China
White light, which contains polychromic visible components, affects the rhythm of organisms and has the potential for advanced applications of lighting, display, and communication. Compared with traditional incandescent bulbs and inorganic diodes, pure organic materials are superior in terms of better compatibility, flexibility, structural diversity, and environmental friendliness. In the past few years, polychromic emission has been obtained based on organic aggregates, which provides a platform to achieve white-light emission. Several white-light emitters are sporadically reported, but the underlying mechanistic picture is still not fully established. Based on these considerations, we will focus on the single-component and multicomponent strategies to achieve efficient white-light emission from pure organic aggregates. Thereinto, single-component strategy is introduced from four parts: dual fluorescence, fluorescence and phosphorescence, dual phosphorescence with anti-Kasha’s behavior, and clusteroluminescence. Meanwhile, doping, supramolecular assembly, and cocrystallization are summarized as strategies for multicomponent systems. Beyond the construction strategies of white-light emitters, their advanced representative applications, such as organic light-emitting diodes, white luminescent dyes, circularly polarized luminescence, and encryption, are also prospected. It is expected that this review will draw a comprehensive picture of white-light emission from organic aggregates as well as their emerging applications.
aggregate white-light emission aggregation-induced emission organic mechanism Advanced Photonics
2022, 4(1): 014001
Author Affiliations
Abstract
1 State Key Laboratory of Luminescent Materials and Devices, Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates, South China University of Technology, Guangzhou 510640, China
2 Department of Chemistry, The Hong Kong University of Science & Technology, Clear Water Bay, Kowloon Hong Kong, China
Since the first report of aggregation-induced emission (AIE) concept in 2001, it has received intense attentions from academy and industry because of its important applications in diverse research fronts. Up to now, the luminogens with AIE property (AIEgens) have been widely used in optoelectronic devices, fluorescent bioprobes and chemosensors, and researchers have also committed to exploring the potentials of AIEgens in other cross-cutting areas. The AIEgens have shown superior advantages such as highly efficient emissions in the aggregated state and thus exhibited better performances in comparison with traditional luminescent materials whose emissions are usually quenched upon aggregate formation. In view of the significant achievements of AIEgens in recent years, this review presents representative advancements of AIEgens for the applications in organic optoelectronic devices, mainly including organic light-emitting diodes (OLEDs), circularly polarized luminescence (CPL) devices, electrofluorochromic (EFC) devices, luminescent solar concentrators (LSCs), and liquid crystal displays (LCDs). Not only the design strategies of AIEgens for these optoelectronic devices are analyzed, but also their structure-property relationship and working mechanism are elucidated. It is foreseeable that robust AIEgens with specific functionalities will find more and more applications in various research fields and play an increasingly important role in high-tech devices.
Author Affiliations
Abstract
1 Centre for Optical and Electromagnetic Research Zhejiang University, Hangzhou 310058, P. R. China
2 Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction Division of Life Science, State Key Laboratory of Molecular Neuroscience Institute for Advanced Study, Institute of Molecular Functional Materials Division of Biomedical Engineering The Hong Kong University of Science and Technology Clear Water Bay, Kowloon, Hong Kong, P. R. China
3 Interdisciplinary Institute of Neuroscience and Technology (ZIINT) Zhejiang University, Hangzhou, 310058, P. R. China
Rodents are popular biological models for physiological and behavioral research in neuroscience and rats are better models than mice due to their higher genome similarity to human and more accessible surgical procedures. However, rat brain is larger than mice brain and it needs powerful imaging tools to implement better penetration against the scattering of the thicker brain tissue. Three-photon fluorescence microscopy (3PFM) combined with near-infrared (NIR) excitation has great potentials for brain circuits imaging because of its abilities of anti-scattering, deeptissue imaging, and high signal-to-noise ratio (SNR). In this work, a type of AIE luminogen with red fluorescence was synthesized and encapsulated with Pluronic F-127 to make up form nanoparticles (NPs). Bright DCDPP-2TPA NPs were employed for in vivo three-photon fluorescent laser scanning microscopy of blood vessels in rats brain under 1550 nm femtosecond laser excitation. A fine three-dimensional (3D) reconstruction up to the deepness of 600 μm was achieved and the blood flow velocity of a selected vessel was measured in vivo as well. Our 3PFM deep brain imaging method simultaneously recorded the morphology and function of the brain blood vessels in vivo in the rat model. Using this angiography combined with the arsenal of rodent's brain disease, models can accelerate the neuroscience research and clinical diagnosis of brain disease in the future.
Three-photon fluorescence microscopy (3PFM) aggregation-induced emission (AIE) deep-tissue imaging in vivo rat brain Journal of Innovative Optical Health Sciences
2019, 12(6):
1 College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 310036, China
2 Guangdong Innovative Research Team, State Key Laboratory of Luminescent Materials and Devices, South China University of Technology,Guangzhou 510640, China
3 Center for Display Research, The Hong Kong University of Science & Technology, Kowloon, Hong Kong, China
4 Department of Chemistry, Division of Biomedical Engineering, Division of Life Science, The Hong Kong University of Science & Technology,Kowloon, Hong Kong, China
By melting tetraphenylethene (TPE) and 1,2,4,5-tetraphenyl-1H-imidazole (TPI) units together through different linking positions, three new fluorophores are synthesized, and their optical, electronic and electroluminescence (EL) properties are fully studied. Owing to the presence of TPE unit(s), these fluorophores are weak emitters in solutions, but are induced to emit strongly in the aggregated state, presenting typical aggregation-induced emission characteristics. The experimental and computational results reveal that different connection patterns between TPE and TPI could impact the molecular conjugation greatly, leading to varied emission wavelength, fluorescence quantum yield and EL performance in organic light emitting diodes (OLEDs). The fluorophore built by attaching TPE unit to the 1-position of imidazole ring shows bluest fluorescence, and its EL device emits at deep blue region (445 nm; CIE = (0.16, 0.15)). And the device based on the fluorophore by linking TPE to the 2- position of imidazole ring shows EL at 467 nm (CIE = (0.17, 0.22)) with good efficiencies of 3.17 cd·A–1, and 1.77%.
aggregation-induced emission (AIE) aggregation-induced emission (AIE) tetraphenylethene(TPE) tetraphenylethene(TPE) imidazole imidazole blue fluorescence blue fluorescence organic organic Frontiers of Optoelectronics
2015, 8(3): 274
